Development plan
Analytical objective, experimental strategy, variables and decision criteria.
Method Development & Validation
A reliable result begins with a method that has proved it can work.
A laboratory method should do more than produce a number. It should consistently measure the right analyte, in the right sample, across the concentration range you actually use. We help laboratories develop, optimise, verify and validate methods with clear scientific reasoning and defensible documentation.
When methods need attention
Good equipment cannot rescue a poorly designed method.
Unexpected peaks, weak recovery, unstable results, matrix interference and poor repeatability are often signs that the method or its validation plan needs to be reconsidered. We help you identify the source of the problem before more time and reagents are lost.
Poor sensitivity or unstable response
We review sample preparation, detector response, concentration range and critical operating conditions.
Matrix interference
We assess the effect of sample composition and develop controls that distinguish the analyte from interfering substances.
Results cannot be reproduced
We examine analyst, day, instrument, reagent and preparation variables that may be driving inconsistency.
Validation records are incomplete
We help organise protocols, raw data, calculations, deviations, acceptance criteria and final conclusions.
Service scope
Support can cover one stage or the complete method lifecycle.
We agree on the analytical objective, matrix, intended use, equipment and reporting expectations before the project begins.
Analytical target and intended-use definition
Literature and compendial method review
Sample preparation optimisation
Instrument-condition optimisation
Method feasibility experiments
Verification and validation protocol development
Accuracy, precision and recovery studies
Specificity, selectivity and interference studies
Linearity, range, LOD and LOQ studies
Robustness and ruggedness assessment
Statistical analysis and acceptance review
Final report, SOP and implementation support
Project pathway
Each decision is linked to the method’s intended purpose.
Method development is iterative. We document why conditions were selected, what was changed and how the final method meets the agreed performance requirements.
1. Define the analytical problem
We identify the analyte, matrix, concentration range, reporting limit, equipment and intended regulatory or research use.
2. Review available methods
Published, compendial and existing in-house methods are assessed for suitability, limitations and adaptation needs.
3. Optimise critical conditions
Sample preparation, reagents, extraction, separation, detection and calculation steps are refined through planned experiments.
4. Verify or validate performance
The method is tested against predefined acceptance criteria using the agreed validation parameters.
5. Document and transfer
We prepare the report, controlled method or SOP, calculation tools and implementation guidance for routine use.
Typical deliverables
A complete evidence package, not just a final number.
Deliverables are tailored to the project and may include the following documents and tools.
Validation protocol
Parameters, procedures, replicates, calculations and acceptance criteria.
Calculation templates
Structured worksheets for data entry, statistics and result review.
Validation report
Results, deviations, interpretation and a clear fit-for-purpose conclusion.
Controlled method or SOP
Step-by-step routine procedure with quality-control requirements.
Risk assessment
Critical method variables, likely failure points and suitable controls.
Staff guidance
Practical training and support for analysts implementing the method.
Method transfer support
Assistance when transferring the method between analysts or laboratories.
Estimated project duration
2–12 weeks
Focused verification may take two to four weeks. Full development and validation may require four to twelve weeks or longer.
Estimated consultancy fee
From ₦300,000
Final pricing depends on the matrix, analyte, method complexity, instrument time, standards, reagents and validation scope.
Important:
Instrument charges, laboratory consumables, certified reference standards, sample procurement, third-party testing and travel are not automatically included. These will be listed separately in your quotation where required.
Common questions
What clients usually ask before commissioning a method project.
Verification confirms that your laboratory can successfully perform an established standard method under its own conditions. Validation is broader and demonstrates that a new, modified or in-house method is fit for its intended purpose.
Yes. We can review the method, intended use, matrix, analyte range, equipment and acceptance criteria, then develop a suitable validation plan and support the experimental work and final report.
This depends on the project. We can design the study and support your laboratory team, perform agreed work through suitable laboratory arrangements, or combine both approaches.
Depending on the method, parameters may include accuracy, precision, specificity, selectivity, linearity, range, detection limit, quantitation limit, robustness, recovery and measurement uncertainty.
A focused verification may take two to four weeks. Full method development and validation commonly takes four to twelve weeks or longer, depending on complexity, sample matrix, instrument availability and the number of validation parameters.
Request a callback
Tell us about the method and the problem you need to solve.
Share the analyte, sample type, available equipment, current method status and intended use. A member of our consultancy team will review your request and contact you.
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